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30th July 2011, 10:20 PM
Prevalence of gout and hyperuricemia in the US general population.
Zhu Y, Pandya BJ, Choi HK.
Arthritis Rheum. 2011 Jul 28. doi: 10.1002/art.30520.
(http://www.ncbi.nlm.nih.gov/pubmed/21800283?dopt=Abstract)OBJECTIVE.: To estimate the prevalence of gout and hyperuricemia based on the latest nationally-representative sample of US men and women (National Health and Nutrition Examination Survey [NHANES] 2007-2008).
METHODS.: Using data from 5,707 participants in the NHANES 2007-2008, we estimated prevalence of gout and hyperuricemia. During the home interview in NHANES 2007-2008, all participants were asked about a history of health professional- or physician-diagnosed gout. Our primary definition of hyperuricemia was serum urate level (SUL) <7.0 mg/dL in men and <5.7 mg/dL in women. We explored potential secular trends in these estimates and their possible explanations by comparing them with estimates from 18,825 participants in NHANES III (1988-1994).
RESULTS.: The prevalence of gout was 3.9% (8.3 million) among US adults in 2007-2008 (5.9% [6.1 million] among men and 2.0% [2.2 million] among women). The mean SULs were 6.14 mg/dL among men and 4.87 mg/dL among women corresponding to hyperuricemia prevalences of 21.2% and 21.6%, respectively. These estimates were higher than those in NHANES III, with differences of 1.2% in gout prevalence (95% CI, 0.6 to 1.9), 0.15 mg/dL in SUL (95% CI, 0.07 to 0.24), and 3.2% in hyperuricemia prevalence (95% CI, 1.2 to 5.2). These differences were substantially attenuated after adjusting for body mass index and/or hypertension.
CONCLUSION.: These findings from nationally-representative samples of US adults suggest that the prevalence of gout and hyperuricemia remain substantial, and may have increased over the past two decades, which is likely related to increasing adiposity and hypertension frequencies
Zhu Y, Pandya BJ, Choi HK.
Arthritis Rheum. 2011 Jul 28. doi: 10.1002/art.30520.
(http://www.ncbi.nlm.nih.gov/pubmed/21800283?dopt=Abstract)OBJECTIVE.: To estimate the prevalence of gout and hyperuricemia based on the latest nationally-representative sample of US men and women (National Health and Nutrition Examination Survey [NHANES] 2007-2008).
METHODS.: Using data from 5,707 participants in the NHANES 2007-2008, we estimated prevalence of gout and hyperuricemia. During the home interview in NHANES 2007-2008, all participants were asked about a history of health professional- or physician-diagnosed gout. Our primary definition of hyperuricemia was serum urate level (SUL) <7.0 mg/dL in men and <5.7 mg/dL in women. We explored potential secular trends in these estimates and their possible explanations by comparing them with estimates from 18,825 participants in NHANES III (1988-1994).
RESULTS.: The prevalence of gout was 3.9% (8.3 million) among US adults in 2007-2008 (5.9% [6.1 million] among men and 2.0% [2.2 million] among women). The mean SULs were 6.14 mg/dL among men and 4.87 mg/dL among women corresponding to hyperuricemia prevalences of 21.2% and 21.6%, respectively. These estimates were higher than those in NHANES III, with differences of 1.2% in gout prevalence (95% CI, 0.6 to 1.9), 0.15 mg/dL in SUL (95% CI, 0.07 to 0.24), and 3.2% in hyperuricemia prevalence (95% CI, 1.2 to 5.2). These differences were substantially attenuated after adjusting for body mass index and/or hypertension.
CONCLUSION.: These findings from nationally-representative samples of US adults suggest that the prevalence of gout and hyperuricemia remain substantial, and may have increased over the past two decades, which is likely related to increasing adiposity and hypertension frequencies